Category: Medicine

  • Morgellons—cranks in search of a disease

    I’m trying to understand “morgellons syndrome”. Based on Morgellons Research Foundation reports, there are a lot of people out there who believe they have this so-called disease. But what is it? I decided to dig deeper on the research end of things. I went to the MRF website, and to MedLine, looking for something, anything, to help me find out more about this problem. I must report that the science doesn’t look good for the morgie boosters.

    First, there has been little legitimate research on morgellons as such. The CDC is doing an epidemiologic study to determine what, if anything, may actually exist.

    The medical consensus is that so-called morgellons is a variant of delusions of parasitosis. It may be, however no case definition exists, and no central registry exists. Each case is treated on its own (and probably should be).

    Since morgellons resembles in every way but name delusions of parasitosis, it is on the morgellons advocates that the burden of proof falls. If they wish to invoke a new diagnosis, they must have a definition, a way of distinguishing morgellons from DOP, and a reasonable hypothesis to investigate. So far, none of these has happened.

    The dermatology literature has treated this phenomenon is a very sensible way. It has been recommended that patients’ feelings and sensations be validated, but that they be told the truth—that there is no evidence of infectious or otherwise primary dermatologic disease. It is sometimes recommended that patients be told that they have a problem with the sensory apparatus in their skin and nervous system, and that medications that act on the nervous system be used. This approach is quite rational, and atypical antipsychotic medications have been used successfully.

    This is in marked contrast to the bizarre approach taken by the morgies. Their “research foundation” has preconceived notions of what is happening—they have formed a conclusion rather than a hypothesis. This is fatal to science.

    Read on….
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  • Flu update

    Continuing my series from WhiteCoat Underground, here is the latest influenza update.

    i-71ff2058c99656a050f7b3ae34ba49f7-usmap10.jpg

    While still widespread, numbers are finally starting to drop. I’m ready to drop myself. It’s been a terrible season—the worst I’ve ever seen. This is probably due, at least in part, to this year’s flu vaccine missing some unanticipated strains.

    For those of you out there who don’t “believe in” flu shots, remember that vaccination isn’t a religion. The anti-vaccination forces are, however, rather cult-like. Here’s some info for you.

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  • Disclaimers and such

    Last updated 09 October 2008

    When writing on medical topics, a few issues are important to address directly, conveniently laid out by the Health on the Net Foundation.

    Medical authority and complementarity, or, “I’m not your doctor”

    We don’t give advice here. Our posts represent our own opinions, thoughts, etc. and no one else’s. Neither our hospitals, partners, universities, nor anyone else has approved of anything we write. The information in our posts is intended for discussion purposes only and not as recommendations on how to diagnose or treat illnesses. Our writings do not claim to represent anyone’s opinions but the author.

    One our authors is a board-certified internist, one a medical student, and one an attorney. Any personal medical issues the reader may have should be referred to the reader’s physician. If the reader freely chooses to use some random anonymous blog to make medical decisions, well, that would be just foolish. See your own doctor, damn it, he’s got boat payments to make.

    Intended Audience

    This blog has a variety of posts written a varying levels of complexity. We have readers in high school, octogenarians, and many in between. Readers have indicated many levels of education from high school to doctorates. All are welcome. Some people will find some posts too simplistic, others too complex. Such is life.

    Confidentiality and Privacy

    Confidentiality is more important than any other principle in medical writing. I always change significant data about clinical cases, which can include gender, place, temporal relationships, and other potentially identifying data. Cases are often amalgams of different patients’ stories.

    Please remember that any information you submit through comments or email are inherently un-secure. If you wouldn’t shout it from the rooftops, don’t send it to me or post it in a comment. That being said, I will never intentionally divulge personal information or contact information of our visitors.

    Type whatever you will, but your email or comment may become the subject of a new post, and that isn’t always a good thing for the commenter.

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  • What Happened?

    Hello?
    (tap tap)
    Hello?
    (tap)
    Is this thing on?

    OK. I think it’s working.

    Wow. I mean, wow. Someone seems to have accidentally dropped the keys to denialism blog on my desk, so now I’m in ur blogz, messing with ur words and stuff.

    That’s really the only logical explanation. I mean, how else could I, a lowly Doctor of Medicine in a dreary Midwestern town, end up writing on Sb?

    I guess I owe you an explanation…
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  • The post in which I continue to attack the damn libertarians

    Also pissing me off this week is the continuing nonsense from Cato’s anti-universal health care club which is suggesting that increasing health care coverage will lead to an increased number of deaths because of increasing medical errors.

    Sack notes that “at least twice as many Americans are estimated to die each year from medical errors as from lack of access to care.” He quotes economists Helen Levy and David Meltzer’s conclusion that there is “no evidence” that expanding coverage would be the best way to improve health and save lives.

    If there is no evidence that expanding coverage would deliver the biggest improvement in health for the money, then expanding coverage could actually increase death and disability compared to a superior policy. I’ll be debating Nichols tomorrow at a meeting of the National Association of Business Economists. Should be a good time.

    Now, if you want to be a libertarian and think of no one but yourself all the time, that’s just freaking great, but it’s totally different if you’re going to start spreading around this crank nonsense about medical errors being a big bad killer. Inherent is this suggestion is that medical care is of net negative benefit, which is totally absurd. And the Institute of Medicine reports on medical errors are poorly understood as people fail to understand two critical aspects of the studies. For one, much of the medical errors resulting in injury have to do with inpatient care and an inpatient population is a really different beast from the types of medicine we’re talking about with universal coverage. People under universal healthcare won’t go into a hospital, lay in a bed for a few days and get a decubitus ulcer because they suddenly have free medical care. Much of the medical “mistakes” described in these reports aren’t really mistakes by doctors but represent fundamental problems with keeping people healthy in hospitals. Much of it has to do with nursing and support care, spread of nosocomial infection, and clerical errors (the last of which we’re improving on with increased digitization) and affecting a population which tends to be very fragile to start with. This stuff simply isn’t relevant to the type of outpatient care universal coverage seeks to provide.

    The second idiocy here is that the type of medicine under a universal health system will hopefully be fundamentally different than what we have now. Currently, doctors are essentially penalized for providing more care, and rewarded by insurance companies for providing less care. There is also completely inadequate support for preventative medicine. Despite these measures to reduce cost we still manage to spend more per capita on healthcare than any other nation, are ranked almost dead last among industrialized nations for provision of care (mostly due to access problems), and have over 40 million uninsured. These facts make a prima facie case for the need to reform our medical delivery system. The current system is unjustifiably stupid economically, and the restructuring of healthcare delivery has the potential to gear medicine more towards better disease prevention, screening, and overall increased quality of care as people are less fearful of being dinged by their insurance company for the crime of getting sick or being diagnosed with a disease.

    The third idiocy is to say the reason for universal healthcare is just improving patient outcomes. We’re also trying to prevent people from being bankrupted, whether they’re insured or not, because of medical problems. Even with insurance illness frequently leads to financial distress and even bankruptcy.

    I want universal health care because I think it is the right thing to do medically, morally, and economically. Our current system is too expensive, poorly designed for delivery of good medical care, and ultimately is biased against people getting the care they need. If you can fix the system under a free-market approach that will prevent people from being financially ruined by health issues, will cover everybody, encourage the widespread adoption of preventative care and not cost five times as much per capita as any other country’s care, I’m all for it. As it stands what we have is too little care for too much money. The best Cato can do is make the absurd argument that more care = more mistakes. By this logic we should just stop all medical care from being provided if mistakes are such a net negative. If that’s the best the defenders of the free market can do, the free market is in trouble.

  • The post in which I pick a fight with Jake

    Has anyone noticed how my sciblings are really ornery at the moment?
    We’ve got PZ bringing out the angry stick over Wilkins’ criticism of Dawkins. Physioprof is getting ready to pop Greg Laden in the nose over this thread (and I tend to agree it needs a rewrite).

    And then Shelley broke my heart by posting
    this video mocking anesthesiologists that I posted a couple months ago. And here I thought my sciblings paid attention to me *sob*.

    Mommy and Daddy fighting and my sciblings ignoring me are making me feel insecure and frightened and as a result I’m going to lash out at Jake for this libertarian nonsense. At issue is this article in the Lancet which makes the suggestion that the poaching of doctors from poor African countries should be banned by international treaty. They make a compelling argument, and I tend to agree that it’s a grossly immoral practice that results in harm to millions.

    But Jake finds it unbelievable. Why?

    What I am aghast at is the cavalier attitude that this article expresses towards the rights of the health care workers in question. In indicating that the health care worker “poaching” violates the rights of Africans, in what way are they construing the rights of the health care workers? Have they concluded that the nations in question are entitled to their own health care workers? Are they implying that the health care workers are a nation’s property?

    True, they do include the obligatory homage to the health care workers’ rights:

    However, this admission contradicts what they say about the rights of African citizens demanding care. Let me make this clear. The authors assert that the individuals in Africa have a right to health care. On the other hand, they assert that the health care workers have right to mobility and the right to pursue a career under any circumstances they find most fortuitous. Does the health care workers right to mobility not include the right to converse with and interact with any organization they choose? The authors seem to suggest that the health care workers should exist is some sort of socially beneficent darkness in which they have rights but no knowledge by which they could appropriately exercise them.

    One of the critical problems here is the failure to recognize that states invest significantly in healthcare worker education. I can’t speak to the policies in each of these nations, but as a generalization, medical education does not occur without state subsidy. Here in the US, entitlement programs contribute about $100k a year for each resident’s training (they get paid about half, and the hospital takes the rest), and medical student education is heavily subsidized by state and federal governments. Your tuition, as ridiculously high as it is, is only a fraction of what it costs to educate a medical student. I also am secretly hoping that Jake is in the MSTP program. It amuses me endlessly when people are libertarians while receiving education that is 100% subsidized (and stipended) by the federal government.

    My point is that yes, the government does have enough invested interest in medical education that they’re naturally going to expect a return for that investment. When rich states actively take doctors from poor states, it’s a truly disgusting and unethical behavior that is effectively stealing money from already strapped states. From the Lancet article:

    In comparison, by recruiting Ghanaian doctors, the UK saved about £65 million in training costs between 1998 and 2002, while their contribution to service provision is estimated at around £39 million a year.30 The benefiting countries should make amends through supporting repatriation of professionals who have left the country, training initiatives, the building and staffing of new health schools, and support for the development of retention frameworks, including improved salaries, pensions, recruitment of retired workers, and rural-worker incentives.

    We have money to pay for healthcare (ok, maybe not but more than these countries). It’s really screwed up that to save money on our healthcare training we’re letting poorer countries do it, then just snag their trained docs.

    Jake however disagrees and brings up some really silly libertarian views on what our rights as Americans entail.
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  • Trauma

    I’ve almost come to the end of the core 8 weeks of my surgery rotation (4 more weeks follow in electives) and am currently working on the trauma service for another couple days before taking exams.

    I don’t have a great deal to say, the hours stay long, the medicine remains interesting etc. I’m enjoying the decrease in laundry that wearing scrubs entails. I enjoy how much doctors tend to take joy in their work. Medicine is a great field that way, as it gives you a feeling of accomplishment as you see what you do day to day really can make a big difference in people’s lives. The debt may be overwhelming, the paperwork endless, and the insurance companies/health policy maddening, but you can see that the satisfaction from the practice of medicine gets them through all the hassles. I’m also amused by the tendency of my attendings to turn to me and say, “don’t blog about this” before saying something funny. Don’t worry guys, I won’t. I’ll just save it for my tell-all book.*

    Trauma is an incredible field, and while I won’t comment on the workload (everyone on the trauma ward is a little superstitious – one never comments on things being slow or fast for fear things will become busy, or worse, crushingly busy) it has been an interesting couple of weeks. In particular, one of the attendings uses a unique teaching technique that I’ll write about later this week (with permission) using simulations that we refer to as War Games. I found it all very interesting and helpful so with luck we’ll have a video of me participating in one of these sessions by the end of the week. I’ll write a post on it then, as I hope it can be implemented more widely in medical education.

    I’d also like to take this opportunity to ask a couple of favors.

    One, I’d very much like people to stop shooting one another. It’s really terrible what bullets do to a body.

    Two, it also might help if you all could wear helmets. If I thought you could avoid hitting your head that would be one thing, but the least you can do is take some precautions. Wear them a lot – riding bikes, motorcycles, skiing, etc. In fact, just wear them all the time. Sitting at your desk? Wear a helmet. Walking in the park? Wear a helmet. We’re going to start a new style right here and now. We’ll call it the “I’m either about to get on a bike or am prone to seizures” look.

    It would make me feel better. Really.

    * Kidding, kidding.

  • Science-based medicine – The good and the bad on a good new blog

    I must say I’ve loved much of the writing at the new blog Science-Based Medicine. These guys are fighting the good fight and presenting very sophisticated aspects of evaluating the medical literature in a very accessible way. In particular I’d like to point out David Gorski’s critique of NCCAM and the directly-relevant articles from Kimball Atwood on the importance of prior probability in evaluating medical research. I mention these as a pair because lately I’ve really become highly attuned to this issue due to the research of John Ioannidis which is critical for understanding which evidence in the literature is high-quality and likely to be true. Atwood rightly points out that pre-study odds, or prior probability is critical for understanding how the literature gets contaminated with nonsense. Stated simply, the emphasis on statistical significance in evidence based medicine is unfortunate because statistical significance is ultimately an inadequate measure of the likelihood of a result being true.

    The scenario goes like this. You have an test, let’s say, the efficacy of magnets in increasing circulation in rats. Because magnets are believed to have some health benefit according to some snake oil salesmen, you and 99 other researchers decide to put this to the test in your rat-based assay. Based on chance alone, as many as 5% of you may get a statistically significant result in your studies that appeared real simply due to chance. 95 of you will then say, “oh well, nuts to this” and shove the data in the file drawer to be forgotten. The other 5% may then say, “wow, look at that” and go ahead and try to publish your results. This is what is known as the file-drawer effect. Positive results get published, negative results do not, thus false positive results, especially ones with big effects will often sneak into the literature. Luckily science has a self-correcting mechanism that requires replication, but since we don’t delete the initial studies, they will always be there for the cranks to access and wave about.

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  • A month into surgery – back to the books

    I’ve just completed my first month of my surgical rotation and still find almost every day fascinating. I just finished a 4-week rotation in the hepatobiliary service (liver, biliary and pancreatic surgeries mostly) and now go on to thoracic for 2 weeks, and then trauma for 2 weeks to complete the core requirement. I’ll also be doing orthopedic trauma and neurosurgical rotations before I’m done in March and I’ll be sure to write about those as well.

    Friday night we had the medical student pimp-off AKA surgical jeopardy. For the uninitiated, pimping refers to the practice of quizzing students on the wards to make sure they’ve been studying (or occasionally to show off one’s own knowledge of medical minutia). For surgical Jeopardy/the pimpoff the residents get all the medstudents on the general service rotations together and quiz them Jeopardy-style. It was a lot of fun, one team even had t-shirts made, everybody was getting pretty into it. I even won a book! Although I’m afraid the smack talk may have gotten out of hand. Oh well.

    i-e46318a9e93054e251c582f20e3ed0e5-books.jpg

    And speaking of books, I’ve just got to write about what it’s like constantly having your nose in one. Above is the ICU Book I won Friday, as well as the Essentials of General Surgery textbook which is more or less required reading for the rotation. Then there is Surgical Recall (my cat is investigating), a book born right here at UVA which consists of several thousands of questions and their answers. It’s kind of a survival guide for the rotation since the questions are the kinds of things you’re likely to be pimped on. Like, what is the gastrinoma triangle?

    Books for me have almost become a form of self-medication. When you start medical school, often fresh out of college, you quickly are overwhelmed by the sheer volume of information you must assimilate. These are the basic science years and in a way the first year is the most difficult. It’s a little bit like trying to drink water out of a fire hydrant. The material isn’t even necessarily challenging, but the sheer overload of information becomes overwhelming.

    Somewhere in the middle of second year though you wake up and realize you’ve adapted to the information flow and suddenly you can rapidly absorb absolutely huge amounts of knowledge. You’re all proud of yourself. It’s great, and studying doesn’t seem to be as much of a chore.

    Now I’m in third year and it’s back to drinking out of the hydrant again. Not only is the sheer amount of material for any given rotation overwhelming, but in addition you’re learning to apply it practically – a very different beast – while trying learn about managing real patients. I think it’s something people seldom appreciate about medicine is just how immense it is, and every field within it you could devote an entire life of study to. For example, wandering around the library looking for the textbooks to prepare for my next rotation I found these two hefty fellas:
    i-aee2f804867f0c3f5d47d229e00cce02-thoracic.jpg
    These are huge volumes, with very dense material. Each subspecialty is daunting. Say you want to study plastic surgery?
    i-663f61bf99709f95c4e8c75778ccfd2a-plastics.jpg
    Or, God-forbid, opthalmology?
    i-ce5f9398d7fbc7cecc29170e1359543f-Opthamology.jpg

    See what I mean? You really get the feelings as you go along the best you can do is dent the surface, and you really appreciate why specialization has become so extensive. Each of these multivolume books contains hundreds of chapters dealing with specific diseases and descriptions of medical therapy or surgical techniques. Each chapter represents the work of an expert in that field who essentially writes a review of the scientific literature and current practice applied to a single problem or family of disorders. And on top of that, since texts are constantly going out of date, they are just the starting point. You must always keep up with the current literature on any given problem as you are treating your patients.

    The amount of information you don’t know becomes overwhelming. Although these days studying is oddly no longer a chore, but one of the few ways I can decrease my anxiety. You see day to day how critical thorough knowledge of medicine is. And when I get nervous about how little I know I compulsively go out buy a book. It’s an expensive habit, but it seems to be the only thing that decreases the stress of having such inadequate knowledge. Hence I’ve become the Amy Winehouse of textbook purchasing.

    Then there is the most frightening thing of all – the realization that the feeling you don’t know enough will probably never go away.

  • Surgeons have cool tools

    Surely no one can be pissed at me for pointing out that surgeons have some of the coolest tools, so I think I’ll describe a few of them that I’ve seen used a great deal in general surgery.

    The one most frequently in use is referred to simply as “the Bovie” and it is used for electrocautery. Named for William Bovie it was first used by the famous surgeon Harvey Williams Cushing almost a century ago. The patient in the OR is laying on a large conductive pad that grounds them, and the Bovie device, which resembles a little plastic pencil with a flat, rounded metal tip, generates an electrical current which is transmitted directly to tissues to cut like a scalpel.
    i-21c22598eaf025d33d6e1a905f53de44-08ElectrocauteryPencil.jpg

    I can’t find a nice video of one in action, but it really is an interesting little device. By generating an alternating current at the tip it rapidly generates a great deal of heat in a very tightly-controlled location. Further, because you aren’t grounded, you can use it in close proximity to your fingers, or touch it to metallic surgical instruments to transmit the current to through the instrument to tissues without burning yourself. The effect of the device is dramatic. On one setting, the cut, a continuous waveform is generated that allows you to cut through tissue like a scalpel. The second setting, coagulation, turns the current on and off rapidly for a slower heat which coagulates while it cuts. The advantage of a Bovie over a scalpel is that a cut can be made that is clean and doesn’t bleed excessively thus maintaining hemostasis. One can also grasp a small vessel with a hemostat (or clamp) and touch the Bovie to the hemostat to rapidly coagulate the vessel to prevent bleeding.

    More below…

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